233 papers
Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.
On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.
Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.
This study demonstrates that in Drosophila male cells lacking roX RNA, the failure of the dosage compensation complex to activate X-linked genes is bypassed by the rapid acquisition of extra X chromosomes, which restores the essential X-to-autosome expression ratio and viability.
This study demonstrates that circadian rhythms regulate macrophage responses to SARS-CoV-1 and SARS-CoV-2 spike proteins by driving time-dependent immunometabolic states characterized by central metabolic and mitochondrial changes rather than classical immune activation.
This study confirms that the invasive mosquito *Anopheles stephensi* is actively transmitting *Plasmodium vivax* in Djibouti, as evidenced by the detection of infective sporozoites in local populations that share genetic characteristics with other invasive strains across the Horn of Africa.
This study utilizes bioinformatic analysis of proteomic data from goat atrial tissue to reveal that atrial fibrillation triggers a coordinated mitochondrial adaptation involving oxidative phosphorylation enrichment and HSPA9-mediated regulation of respiratory chain complexes.
This study demonstrates the potential of intraperitoneal vivo-morpholino injections for transient gene knockdown in adult threespine stickleback, achieving successful knockdown of the *Spi1b* gene in the spleen despite variable delivery efficiency across target organs.
This study demonstrates that the structured RNA-binding domains and condensation capacity of the ALS-linked protein FUS function as distinct yet synergistic mechanisms to shape its RNA-binding landscape, thereby governing nuclear condensate assembly, DNA damage response, and transcriptional regulation.
This study reveals that a conserved, negatively charged intrinsically disordered region in mammalian Dicer acts as an autoinhibitory element that stabilizes a pre-dicing state to ensure the high-fidelity processing of microRNA precursors while suppressing broader RNAi activity.
This study demonstrates that long-read sequencing of the 18S rRNA gene provides superior taxonomic resolution and a more robust representation of freshwater biofilm communities compared to short-read methods, highlighting the critical impact of sequencing strategy on eDNA-based biomonitoring accuracy.
This study reveals that the conserved long non-coding RNA ACHLYS regulates alternative splicing during Arabidopsis root development by directly interacting with the splicing factor NSRa to modulate its biomolecular condensates and phase separation, thereby fine-tuning the transcriptome output essential for organogenesis.
This study resolves the paradox of cohesin's modest impact on steady-state gene expression by demonstrating that it acts as a transcriptional gatekeeper which simultaneously promotes Pol II recruitment and restrains pause release to ensure transcriptional processivity and robust induction in response to stimuli.